Cold Spring Harbor Laboratory
Genes Can Be Moved Between Species
Biotechnology changes lives every day, but how did it all start? Learn about Cohen and Boyer's technique for recombinant DNA and the founding of this new scientific study. Then, scholars use the online interactive to discover how Hanahan...
Howard Hughes Medical Institute
Color Variation Over Time in Rock Pocket Mouse Populations
While many mutations are neutral, those that appear advantageous increase in frequency in a population. Scholars use illustrations to make predictions about populations of mice. They follow it up with a video to confirm or refute their...
Howard Hughes Medical Institute
Molecular Genetics of Color Mutations in Rock Pocket Mice
Can you identify mutations just by viewing DNA sequences? Scholars apply prior knowledge of DNA sequences to do just that in an engaging activity. They transcribe and translate genes, thus identifying the locations of mutations. Then,...
Howard Hughes Medical Institute
Biochemistry and Cell Signaling Pathway of the Mc1r Gene
How do mice have so much fur color variation over generations? Scholars illustrate protein structures based on amino acid sequences. Then, they analyze the signaling pathway in different-colored mice populations. This allows them to...
Howard Hughes Medical Institute
Natural Selection and Evolution of Rock Pocket Mouse Populations
Can evolution repeat itself? Scholars analyze amino acid data in two separate populations of mice. They learn that evolution repeats itself, but natural selection prefers some mutations over others in different environments. Analysis...
Howard Hughes Medical Institute
Population Genetics, Selection, and Evolution
The Hardy-Weinberg principle states that alleles and genotypes remain constant in the absence of evolutionary influences. Scholars complete a simple hands-on activity applying the Hardy-Weinberg principle to sample data. They observe how...
Cold Spring Harbor Laboratory
Living Things Share Common Genes
Everything evolved from a common ancestor, but how did modern plants and animals develop so many more genes? Scholars use an online interactive to learn about the process. They begin to understand common genes with an animation, multiple...
Cold Spring Harbor Laboratory
A Genome Is an Entire Set of Genes
Today researchers identify a gene suspected of causing a genetic disease in a matter of days rather than years, thanks to the Human Genome Project. Young scientists learn about the Human Genome Project and the scientists who designed the...
Cold Spring Harbor Laboratory
Development Balances Cell Growth and Death
Cells demonstrate a life cycle like other living things, but what if death was no longer part of the cycle? Learn about the important balance requiring death to continue functioning. An online interactive introduces a group of scientists...
Cold Spring Harbor Laboratory
Different Genes Are Active in Different Kinds of Cells
Personalized medicine prevents many trial-and-error scenarios when time counts the most. Learn how gene expression and screening genomes improves health outcomes in cancer patients, those with auto-immune disorders, and more. An online...
Cold Spring Harbor Laboratory
Genes Can Be Turned On and Off
Regulations exist in many places from business to schools, but what about in our genes? Learn about gene regulation with an online interactive. It uses an animation to introduce the topic, many photographs of the scientists best known...
Cold Spring Harbor Laboratory
Some DNA Can Jump
Some people have a natural ability to jump, but did you know DNA also naturally jumps? Learn about the fun habit by looking at the research of a pioneering female scientist. Barbara McClintock fought prejudice and surpassed her mentors...
Cold Spring Harbor Laboratory
Some DNA Does Not Encode Protein
Roy John Britten easily earned a PhD in nuclear physics—but he found painting with water colors too difficult. Young scientists learn about Britten's life, career, and research with an online interactive. They read a biography, view...
Cold Spring Harbor Laboratory
DNA Is Packaged in a Chromosome
Roger Kornberg, the oldest son of two biochemists, won the 2006 Nobel Prize in Chemistry. Learn about Kornberg and his scientific research with an animation, videos, biography, and an applied problem-solving activity. A summary and...
Cold Spring Harbor Laboratory
Some Types of Mutations Are Automatically Repaired
Does natural light damage or repair DNA? Learn the answer discover the scientists who researched the topic with an online interactive. Scholars read through an online animation presenting the content at their own pace. Then, they read...
Cold Spring Harbor Laboratory
RNA Was the First Genetic Molecule
Can organic molecules come from a pre-biotic environment? Stanley Lloyd Miller proved it is possible when exactly the right conditions exist. Learn about his experiment and the other experiments later building off of it that changed the...
Cold Spring Harbor Laboratory
Some Viruses Store Genetic Information in RNA
Can a high school program alter the entire course of your life? David Baltimore and Howard Temin participated in high school programs working in research laboratories and went on to win the 1975 Nobel Prize. Learn about these two...
Howard Hughes Medical Institute
Weighing the Evidence for a Mass Extinction Part 2: On Land
What can fossils tell us about periods of extinction? Young scholars interpret fossil layers to make conclusions about changes in life during different geological time periods. They analyze the fossils for abundance and diversity as well...
Cold Spring Harbor Laboratory
DNA Is Only the Beginning for Understanding the Human Genome
Mario Capecchi requested funding for a new procedure targeting genes and was rejected. Four years later, after he proved it worked, the NIH apologized and funded his research. Use an online interactive to learn about his research and the...
Cold Spring Harbor Laboratory
Master Genes Control Basic Body Plans
Have you ever been so tired you missed a major announcement? Eric Wieschaus woke to a call explaining he won the Nobel Prize, but he thought it was just a dream until Christiane Nusslein-Volhard, a co-winner, explained it to him later...
Cold Spring Harbor Laboratory
DNA Responds to Signals from Outside the Cell
How do cells know when to replicate, transcribe, and stop? James E. Darnell, Jr. shifted from studying medicine to biochemistry and decided to address this mystery. Learn about his research, discoveries, and the impact on future medical...
Cold Spring Harbor Laboratory
Higher Cells Incorporate an Ancient Chromosome
Chromosomes contain keys to history including links from royalty to Neanderthals. Young scientists learn about Ivan Wallin's research into chromosomes with an animation and videos. Then, the concept connects to mysteries related to...
Cold Spring Harbor Laboratory
Mutations Are Changes in Genetic Information
A red delicious apple tree with a simple mutation means we now benefit from the existence of golden delicious apples. Learn how simple mutations change genetic information in DNA sequences. Using biographies, videos, and animations,...
Cold Spring Harbor Laboratory
The RNA Message Is Sometimes Edited
In 1993, Phillip Sharp and Richard Roberts won the Nobel Prize for their discovery of split gene theory. Learn about the breakthrough with the help of an online interactive. Hear both scientists explain it in their own words, watch an...