History.com: The Native American Chief Who Drove Out Spanish Colonists and Nearly Expelled the English

In the summer of 1561, Spanish explorers abducted Opechancanough, a Powhatan Indian youth from the Chesapeake Bay tidewater region and brought him to the royal court of Spain. The kidnapping set off a chain of events that would alter the course of American colonial history. Opechancanough used what he learned of the Europeans to lead his people against two of the world's greatest powers.