Howard Hughes Medical Institute
Fact Patterns: A Film Guide
What does it take to create a scientific theory? Learners attempt to answer the question by studying the work of Charles Darwin and Alfred Russel Wallace. While watching a video, they track observations from each scientist and then look...
Howard Hughes Medical Institute
Following the Trail of Evidence
One important skill in analyzing scientific evidence is identifying facts versus opinions. Scholars identify pieces of evidence from the film The Day the Mesozoic Died and then discuss this evidence in small groups at the end of each act...
Howard Hughes Medical Institute
Pedigrees and the Inheritance of Lactose Intolerance
What, exactly, causes lactose intolerance? Scholars view a video describing a Finnish study that determined why some people are tolerant while others are intolerant. They then use the data from the study to reenact the experiment and...
Cold Spring Harbor Laboratory
Genes Can Be Moved Between Species
Biotechnology changes lives every day, but how did it all start? Learn about Cohen and Boyer's technique for recombinant DNA and the founding of this new scientific study. Then, scholars use the online interactive to discover how Hanahan...
Howard Hughes Medical Institute
Testing a Hypothesis
Are sickle cell disease and malaria related somehow? Scholars learn about both illnesses and the hypotheses that they are related. They discuss, view a video, and answer questions to demonstrate understanding. The resource includes an...
Howard Hughes Medical Institute
Color Variation Over Time in Rock Pocket Mouse Populations
While many mutations are neutral, those that appear advantageous increase in frequency in a population. Scholars use illustrations to make predictions about populations of mice. They follow it up with a video to confirm or refute their...
Howard Hughes Medical Institute
How Do Fibers Form?
The proteins inside a cell determine the shape of the cell. While most red blood cells have a circular shape, those with sickle cell take the shape of a sickle. This change in shape causes multiple issues in the system. Scholars solve...
Howard Hughes Medical Institute
Population Genetics, Selection, and Evolution
The Hardy-Weinberg principle states that alleles and genotypes remain constant in the absence of evolutionary influences. Scholars complete a simple hands-on activity applying the Hardy-Weinberg principle to sample data. They observe how...
Cold Spring Harbor Laboratory
Living Things Share Common Genes
Everything evolved from a common ancestor, but how did modern plants and animals develop so many more genes? Scholars use an online interactive to learn about the process. They begin to understand common genes with an animation, multiple...
Cold Spring Harbor Laboratory
A Genome Is an Entire Set of Genes
Today researchers identify a gene suspected of causing a genetic disease in a matter of days rather than years, thanks to the Human Genome Project. Young scientists learn about the Human Genome Project and the scientists who designed the...
Cold Spring Harbor Laboratory
Development Balances Cell Growth and Death
Cells demonstrate a life cycle like other living things, but what if death was no longer part of the cycle? Learn about the important balance requiring death to continue functioning. An online interactive introduces a group of scientists...
Cold Spring Harbor Laboratory
Different Genes Are Active in Different Kinds of Cells
Personalized medicine prevents many trial-and-error scenarios when time counts the most. Learn how gene expression and screening genomes improves health outcomes in cancer patients, those with auto-immune disorders, and more. An online...
Cold Spring Harbor Laboratory
Genes Can Be Turned On and Off
Regulations exist in many places from business to schools, but what about in our genes? Learn about gene regulation with an online interactive. It uses an animation to introduce the topic, many photographs of the scientists best known...
Cold Spring Harbor Laboratory
Some DNA Can Jump
Some people have a natural ability to jump, but did you know DNA also naturally jumps? Learn about the fun habit by looking at the research of a pioneering female scientist. Barbara McClintock fought prejudice and surpassed her mentors...
Cold Spring Harbor Laboratory
Some DNA Does Not Encode Protein
Roy John Britten easily earned a PhD in nuclear physics—but he found painting with water colors too difficult. Young scientists learn about Britten's life, career, and research with an online interactive. They read a biography, view...
Cold Spring Harbor Laboratory
DNA Is Packaged in a Chromosome
Roger Kornberg, the oldest son of two biochemists, won the 2006 Nobel Prize in Chemistry. Learn about Kornberg and his scientific research with an animation, videos, biography, and an applied problem-solving activity. A summary and...
Cold Spring Harbor Laboratory
Some Types of Mutations Are Automatically Repaired
Does natural light damage or repair DNA? Learn the answer discover the scientists who researched the topic with an online interactive. Scholars read through an online animation presenting the content at their own pace. Then, they read...
Cold Spring Harbor Laboratory
RNA Was the First Genetic Molecule
Can organic molecules come from a pre-biotic environment? Stanley Lloyd Miller proved it is possible when exactly the right conditions exist. Learn about his experiment and the other experiments later building off of it that changed the...
Cold Spring Harbor Laboratory
Some Viruses Store Genetic Information in RNA
Can a high school program alter the entire course of your life? David Baltimore and Howard Temin participated in high school programs working in research laboratories and went on to win the 1975 Nobel Prize. Learn about these two...
Howard Hughes Medical Institute
Weighing the Evidence for a Mass Extinction Part 2: On Land
What can fossils tell us about periods of extinction? Young scholars interpret fossil layers to make conclusions about changes in life during different geological time periods. They analyze the fossils for abundance and diversity as well...
Cold Spring Harbor Laboratory
DNA Is Only the Beginning for Understanding the Human Genome
Mario Capecchi requested funding for a new procedure targeting genes and was rejected. Four years later, after he proved it worked, the NIH apologized and funded his research. Use an online interactive to learn about his research and the...
Cold Spring Harbor Laboratory
Master Genes Control Basic Body Plans
Have you ever been so tired you missed a major announcement? Eric Wieschaus woke to a call explaining he won the Nobel Prize, but he thought it was just a dream until Christiane Nusslein-Volhard, a co-winner, explained it to him later...
Cold Spring Harbor Laboratory
DNA Responds to Signals from Outside the Cell
How do cells know when to replicate, transcribe, and stop? James E. Darnell, Jr. shifted from studying medicine to biochemistry and decided to address this mystery. Learn about his research, discoveries, and the impact on future medical...
Cold Spring Harbor Laboratory
Higher Cells Incorporate an Ancient Chromosome
Chromosomes contain keys to history including links from royalty to Neanderthals. Young scientists learn about Ivan Wallin's research into chromosomes with an animation and videos. Then, the concept connects to mysteries related to...