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Lesson Plan
Curated OER

Determining Cutting Site Locations

For Teachers 7th - 12th
Learners explore DNA restriction mapping. They cut pieces of paper into lengths representing those produced when specific enzymes are used to cut a strand of DNA.
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Lesson Plan
Curated OER

Science Lesson: Chocolate Flavored Cherries

For Teachers 9th - 12th
Students are able to identify start and stop sequences in DNA. They are able to model using restriction enzyme and ligase to remove sections of DNA and reattach them. Students are introduced to the process of recombinat DNA through the...
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Worksheet
Curated OER

Who Ate The Cheese?!

For Students 10th - 12th
In this crime scene investigation worksheet, students simulate DNA sequencing and DNA restriction analysis using paper strips of DNA. Students compare the crime scene DNA to the suspects and determine who is guilty.
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Lesson Plan
Curated OER

Cut-off Genes

For Teachers 9th - 12th
Investigate the relationships between different deep-sea organisms by DNA sequencing. A worksheet provides instructions for DNA sequencing and space to work. They simulate gel electrophoresis by cutting out paper "DNA strands." Modeling...
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Lesson Plan
Curated OER

Simulation of Gene Splicing

For Teachers 9th - 12th
High schoolers use the exercise as a prelude to a "wet" lab or as a substitute for such a lab. It correlates well with colony transformation labs. This lab is recommended for students what have difficulty with the abstractions that...
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Lesson Plan
Curated OER

DNA Fingerprinting with Restriction Enzymes

For Teachers 6th - 12th
Learners will illustrate how restriction enzymes work by piecing together parts of a puzzle. Then they apply this knowledge to help them analyze genetic evidence from the scene of a crime as well as to help them comprehend how a DNA...
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Lesson Plan
Curated OER

Restriction Digest + DNA Comparison

For Teachers 9th - 12th
High schoolers compare different DNA and run a gel electrophoresis.  For this DNA lesson students complete a DNA activity that allows them to better understand its structure and function. 
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Activity
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Teach Engineering

DNA Forensics and Color Pigments

For Teachers 9th - 12th
Use food coloring in electrophoresis. The last segment in a four-part series mimics DNA fingerprinting by using chromatography. Teams conduct chromatography on food coloring to find colors that use similar pigmentation in their makeup.
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Lesson Plan
Curated OER

Molecular Explorations

For Teachers 9th - 12th
Students explain the processes for separating DNA from tissue and separating complex mixtures.  In this exploratory lesson plan students complete a lab where they extract DNA.  
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Lesson Plan
Curated OER

DNA Race Track

For Teachers 12th
Twelfth graders simulate a DNA fragment running through a gel electrophoresis in a class activity. Students work in teams as a DNA sample with each person on the team representing a fragment that moves through the gel at a specific speed.
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Lesson Plan
Curated OER

Cracking the Code - Cloning Paper Plasmid

For Teachers 10th - 11th
Students explore the "genetic code." They observe how genes may be manipulated for genetic research, gene cloning, and genetic engineering. In a lab setting, students examine the mechanics involved in cutting and ligating DNAs into a...
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Lesson Plan
Curated OER

Macro-DNA: Doing DNA Fingerprinting

For Teachers 9th - 11th
Students explore gel electrophoresis using paper models. They model DNA sequences and shade the boxes on their Gel Electrophoresis Sheet which represent the individual fragments.
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Lesson Plan
Curated OER

GenEng

For Teachers 7th - 9th
Students investigate the process of genetic engineering. In this genetic engineering lesson plan, students use paper models of DNA and plasmid bacterium to investigate the process of replicating DNA, splicing genes from DNA, and...
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Lesson Plan
Curated OER

Genetic Engineering/Biotechnology

For Teachers 12th - Higher Ed
Students create a paper model of a plasmid and insert a DNA molecule that contains a specific gene into the plasmid. They complete an actual transformation involving E. coli bacterium and relate the two activities to one another.
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Lesson Plan
Curated OER

Simulation of Gene Splicing

For Teachers 10th - 12th
Students simulate gene splicing by examining bacteria. They create a bacterial DNA into which they insert the human DNA (gene) that codes for growth hormone. They cut the sites of the enzyme to study how the human DNA can be joined to...
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Lesson Plan
Curated OER

Genetics and Molecular Biology

For Teachers 9th - 10th
Students create DNA models using colored construction papers. In this biology lesson plan, students identify enzyme restriction sites. They model how DNA plasmids replicate when taken up by a bacterial cell.
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Lesson Plan
Curated OER

How to Conquer a Genetic Disease

For Teachers 10th - 12th
Students study the details of DNA restriction analysis and how RFLP's are used to locate genes on a map of DNA.
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Lesson Plan
Curated OER

Wolf Pack in a Bottle

For Teachers 9th - 12th
Learners participate in an activity of a mock electrophoresis using paper chromatography to study DNA and genetic restriction mapping.
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Unit Plan
Kenan Fellows

Unit 2: DNA Analysis

For Teachers 9th - 12th Standards
Ever wonder how they solve those mysterious murders in TV crime dramas? The second of four units in a Biotechnology series introduces scholars to the many methods of DNA analysis. Pupils create and run their own gel electrophoresis...
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PPT
Curated OER

A Little More Advanced Biotechnology Tools: Better Plasmids

For Teachers 9th - 12th
A nice set of information that will help your students understand the process of using recombinant plasmids. DNA hybridization and blotting mechanisms help illustrate expressed genes and the concepts behind the Human Genome Library....
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PPT
Curated OER

A Little More Advanced Biotechnology Tools; Better Plasmids

For Teachers 10th - 12th
After using this DNA and plasmids slide show, the steps of the delicate procedures of southern blotting and DNA libraries should be more clear to your students.  Students will read the guidelines and are also prompted to answer questions...
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Lesson Plan
Curated OER

Macro-DNA: Doing DNA Fingerprinting and Gel Electrophoresis

For Teachers 10th - 12th
Students create numbered DNA sequences by taping together the order of the sequence. They count the number of bases in their RFLP's and shade the boxes on their Gel Electrophoresis sheets that represent individual fragments. They...
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Worksheet
Curated OER

DNA Fingerprinting Simulation

For Students 8th - 10th
In this DNA fingerprinting simulation worksheet, students perform an activity that represents using a gel electrophoresis. Students decide who commits a crime in a forensics style lab.
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Lesson Plan
Curated OER

Lost Baby

For Teachers 9th - Higher Ed
Students simulate the steps involved in creating a DNA fingerprint by the RFLP technique. They analyze RFLP patterns to determine the parentage of a missing baby.