Read's mother was the daughter of a Welsh planter, and his Dublin-born father a landholder of means. Soon after George's birth in 1733 near the village of North East in Cecil County, MD, his family moved to New Castle, DE, where the youth, who was one of six sons, grew up. He attended school at Chester, PA, and Rev. Francis Alison's academy at New London, PA, and about the age of 15 he began reading with a Philadelphia lawyer.